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Effect of delayed graft function on longer‐term outcomes after kidney transplantation from donation after circulatory death donors in the UK: A national cohort study

American Journal of Transplantation Mar 29, 2021

Phillips BL, Ibrahim M, Greenhall G, et al. - A worldwide variability has been observed in utilization of kidneys from donation after circulatory death (DCD) donors, this is in part due to high rates of delayed graft function (DGF) and putative correlations with adverse longer‐term outcomes. Researchers herein examined if the presence of DGF, and its duration, were linked with poor longer‐term outcomes after kidney transplantation from DCD donors. A total of 4,714 kidney‐only transplants from controlled DCD donors to adult recipients were identified between 2006‐2016 using the UK transplant registry; 2,832 of the recipients (60·1%) had immediate graft function and 1,882 (39.9%) had DGF. Findings revealed no correlation of the presence of DGF with inferior long‐term graft or patient survivals after risk adjustment. Shorter periods of DGF exhibit no adverse influence on graft or patient survival after DCD donor kidney transplantation. DGF > 14 days was identified to be a novel early biomarker for significantly worse longer‐term outcomes.

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