Louveau B, et al. - Experts evaluated the risk of 5-year radiographic progression taking into account both baseline characteristics and the cumulative time-varying exposure to corticosteroids or DMARDs. They included patients of the Etude et Suivi des Polyarthrites Indifférenciées Récentes cohort meeting the 1987 ACR or 2010 ACR/EULAR criteria for RA at inclusion and having complete radiographic data at baseline and 5 years. Results demonstrated that an important role in radiographic progression was played by corticosteroids and bDMARDs. In RA patients, accounting for treatment class and intensity of exposure consideration in predictive models of radiographic progression was a major concern.