Yu Q, et al. - Researchers conducted this retrospective study to assess the influence of continuous metformin therapy on kidney function after coronary intervention for ST-segment elevation myocardial infarction (STEMI). In the meantime, the independent predictors of contrast induced-acute kidney injury (CI-AKI) have been explored using multiple logistic regression analysis. A total of 284 consecutive T2DM patients with STEMI were enrolled in the study showing an onset of symptoms < 12 h. All patients had an estimated glomerular filtration rate (eGFR) > 30 mL/min/1.73 m². There is no statistical disparity in incidence of CI-AKI between the continuous and the discontinuous metformin group. According to multivariable logistic regression analysis, eGFR ≤ 60 ml/min/1.73 m² and contrast volume were predictive factors of CI-AKI. Findings suggested that the continuation of metformin after primary PCI for STEMI did not raise the risk of CI-AKI in diabetic patients with eGFR > 30 ml/min / 1.73 m². This research found no case of lactic acidosis.