Ficociello LH, Zhou M, Mullon C, et al. - In this study, the observed trends in single pool Kt/V, intact parathyroid hormone (iPTH), and serum calcium levels were similar among clinics that switched from acetate-acidified dialysate (AAD) to citrate-acidified dialysate (CAD) vs the geographically matched AAD clinics. These observations back CAD as a potential alternative to AAD in hemodialysis.

• In this retrospective cohort study, several clinical parameters were compared from eligible patients who underwent in-center hemodialysis thrice-weekly in geographically matched CAD (n=3) or AAD clinics (n=12).

• No significant difference in pre-dialysis iPTH was found from baseline to 6-month follow-up within either CAD or AAD clinics.

• Moreover, similar mean change from baseline to month 6 in iPTH was evident between patients (n=142) in CAD clinics (− 17 pg/mL) and patients (n=671) in AAD clinics (13 pg/mL).

• No significant differences existed in the mean change in serum calcium levels and dialysis adequacy (single pool Kt/V) between CAD and AAD clinics.