Agarwal A, et al. - Researchers focused on the link of chronic kidney disease (CKD) with recurrent stroke in this post hoc analysis of the SPS3 Trial. They also investigated the impact of baseline renal function on the influences of intensive systolic blood pressure control in patients with previous stroke. Randomization to a systolic blood pressure target of < 130 mmHg vs 130 to 149 mmHg was performed among 3,020 patients with recent MRI–defined symptomatic lacunar infarctions. This study included 3,017 patients with baseline estimated glomerular filtration rate measurements. In patients with previous lacunar stroke, the risk of recurrent stroke was found to be increased by 50% in correlation with the presence of CKD. No definitive evidence demonstrating a renal dysfunction-induced modification of the impacts of systolic blood pressure control in patients with previous stroke was found.