Nienov OH, et al. - Non-diabetic obese subjects with low-high-density lipoprotein cholesterol (L-HDL-C) or normal (N-HDL-C) levels of HDL-C were investigated following laparoscopic bariatric surgery (BS) for changes in their serum high-density lipoprotein cholesterol. Researchers examined whether increased HDL-C could be correlated with weight loss, serum non-HDL-C, serum triglycerides, and physical activity (PA) before and 6 and 15 months after BS. Evaluation of 71 subjects undergoing BS (42 by Roux-en-Y gastric bypass and 29 by sleeve gastrectomy) was done in this prospective cohort study. Fifteen months following BS, significantly increased levels of HDL-C were noted among subjects with low or normal values at baseline. Both groups (L-HDL-C and N-HDL-C) showed a similar % Excess Weight Loss (%EWL), decrease in WC, glucose, non-HDL-C, and LDL-C levels and an increase in energy expenditure related to PA, at 15 months after BS. However, the L-HDL-C group vs N-HDL-C group showed a greater reduction in TG levels. Subjects with increased HDL-C 15 months after BS displayed an association between this increase and the %EWL, however, no association with the change in PA was observed.