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Effect of antihypertensive medications on sepsis-related outcomes: A population-based cohort study

Critical Care Medicine Apr 17, 2019

Kim J, et al. - Researchers determined the impact of the administration of antihypertensive drugs pre-sepsis on sepsis-related outcomes in patients with hypertension. They used the database of the National Health Insurance Service (2003-2013) and examined patients aged > 30 years who received a diagnosis of sepsis following receiving antihypertensive drugs in South Korea. They noted the association of lower mortality rate with prior use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers not with use of calcium channel blockers or thiazides in patients with sepsis. In prior use of calcium channel blockers, a significantly lower need for inotropic agents was evident, with no prominent survival benefits.

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