Binkowski BJ, et al. - Researchers assessed changes in electrophysiological parameters of the heart muscle and conduction system as a response to increasing doses of antazoline patients undergoing electrophysiologic study (EPS) and radiofrequency (RF) ablation. The following electrophysiological parameters were assessed: sinus rhythm cycle length (SRCL), AH, HV, QRS, QT, QTc intervals, Wenckebach point (WP), sinus node recovery period (SNRT), intra- (hRA-CSos) and interatrial conduction time (hRA-CSd), right and left atrium refractory period (RA- and LA-ERP), and atrioventricular node refractory period (AVN-ERP). With a rapid onset of action, antazoline was shown to have an impact on electrophysiological parameters of the atrial muscle. No negative impact on sinus node function and atrioventricular conduction was seen.