Effect of alcohol consumption on survival in nonalcoholic fatty liver disease: A national prospective cohort study
Hepatology Aug 16, 2019
Hajifathalian K, et al. - By analyzing data from 1988 to 2010 from participants in the National Health and Nutrition Examination Survey, linked to the National Death Index, researchers assessed survival in correlation with alcohol consumption in patients with nonalcoholic fatty liver disease (NAFLD), using multivariate Cox proportional hazards models. They used a previously validated biochemical model (Hepatic Steatosis Index) to diagnose NAFLD. This study included 4,568 participants with NAFLD following the exclusion of participants with significant alcohol use, viral hepatitis, or increased transferrin saturation. A significant reduction in all-cause mortality was observed among patients with NAFLD in correlation with modest alcohol consumption, whereas an increase in mortality was evident in relation to drinking ≥ 1.5 drinks per day.
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