He X, Dong B, Xue R, et al. - This study was undertaken to investigate the differential response to aggressive diuresis in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Researchers included a total of 300 patients in the Diuretic Optimization Strategies Evaluation trial with left ventricular ejection fraction measurement (n = 300) and classified them into HFrEF [left ventricular ejection fraction (LVEF) < 40%] (n = 193) and HFpEF (LVEF ≥ 40%) (n = 107). They compared the effect of high-dose vs. low-dose furosemide strategy separately in HFrEF and HFpEF. The findings revealed that acute heart failure on the basis of HFrEF and HFpEF responded differently to aggressive diuresis. Further studies should be designed separately for HFrEF and HFpEF.