Clemmesen CG, et al. - In order to see if a single, pre-operative intravenous dose of 125 mg methylprednisolone could reduce the severity and/or incidence of postoperative delirium, a single-centre, randomised, double-blind, placebo-controlled trial of older hip fracture patients was conducted. Findings did not suggest any major adverse reactions related to methylprednisolone. The severity of postoperative delirium was not reduced by a single, pre-operative dose of 125 mg methylprednisolone. However, both the prevalence of delirium and the severity of fatigue after hip fracture surgery in older patients, enabling remobilisation and recovery may be reduced by it.