Walker D, Otieno P, Butrick E, et al. - Researchers conducted this unblinded cluster-randomized controlled trial to evaluate the impact of a quality improvement package for intrapartum and immediate newborn care on stillbirth and preterm neonatal survival in Kenya and Uganda, where evidence-based practices are often underutilized. This trial was carried out in western Kenya and eastern Uganda at facilities that provide 24-h maternity care with at least 200 births per year. Eligible facilities have been pair-matched and randomly assigned (1:1) into either the intervention group or the control group. Liveborn or fresh stillborn infants weighing between 1,000 g and 2,500 g or less than 3,000 g with a gestational age of less than 37 weeks have been included in the analysis. Twenty facilities were randomly assigned to either the intervention group (n = 10) or the control group (n = 10) between October 1, 2016, and April 30, 2019. Among the 5,343 eligible infants in these facilities, they evaluated the outcomes of 2,938 newborn and fresh stillborn infants (1,447 in intervention and 1,491 in the control group). No harm or adverse effects have been identified. Fresh stillbirth and neonatal mortality among low birth weight and preterm infants can be reduced through a package of interventions that reinforces evidence-based practices and invests in strengthening the healthcare system.