Wijnberge M, Geerts BF, Hol L, et al. - A preliminary unblinded randomized clinical trial was conducted to investigate whether the clinical application of the early warning system in combination with hemodynamic diagnostic guidance and treatment protocol reduces intraoperative hypotension. Between May 2018 and March 2019, researchers conducted this study in a tertiary center in Amsterdam, the Netherlands, among 68 adult individuals scheduled for elective noncardiac surgery under general anesthesia and an indication for continuous invasive blood pressure monitoring. Individuals were allocated randomly to receive either the early warning system (n = 34) or standard care (n = 34), with a goal mean arterial pressure of at least 65 mm Hg in both groups. It was indicated that the usage of a machine learning–derived early warning system compared with standard care appeared in less intraoperative hypotension in this single-center preliminary study of individuals undergoing elective noncardiac surgery. Future study with larger study populations in diverse settings is required to evaluate the impact on additional patient outcomes and to fully assess safety and generalizability.