Effect of a low-dose dexmedetomidine infusion on intraoperative hemodynamics, anesthetic requirements and recovery profile in patients undergoing lumbar spine surgery
Journal of Anaesthesiology Clinical Pharmacology Jul 02, 2019
Kundra S, et al. - Among patients undergoing lumbar spine surgery in the prone position, researchers determined how intraoperative hemodynamics, blood loss, anesthetic needs, and recovery profile were influenced by a low-dose dexmedetomidine infusion. Participants were patients scheduled for one- or two-level lumbar laminectomy (n=60). This investigation was performed in a randomized double-blinded manner. The patients were given general anesthesia and thereafter were placed in prone position and assigned to either of two groups of 30 patients each. Dexmedetomidine infusion at the rate of 0.3 μg kg-1 hr-1 was administered in patients in Group A, whereas, a saline infusion was administered to group B patients. Findings revealed stable hemodynamic parameters, attenuated intraoperative blood loss, less anesthetic need, and earlier extubation in group A patients vs group B patients.
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