Dorenbos E, Drummen M, Adam T, et al. - Researchers conducted this randomized clinical trial to evaluate the change in insulin resistance (IR), analyzed by Homeostatic Model Assessment of IR (HOMA‐IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. They assumed that a high protein/low glycaemic index diet would be superior in decreasing IR compared with a medium protein/medium GI diet, in insulin-resistant adolescents with overweight or obesity. Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom, and Spain have been randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. One hundred twenty-six adolescents were included in this investigation. The PREVIEW study found no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR due to lack of feasibility, due to insufficient retention and dietary compliance after 2 years.