Koga T, et al. - Authors ascertained the impact of leuprolide acetate, a synthetic gonadotropin-releasing hormone analog (GnRH-a) on ovarian function preservation in systemic lupus erythematosus (SLE) patients treated with cyclophosphamide (CYC) in clinical practice. Findings suggested an association of the combined use of GnRH-a with intravenous CYC (IVCY) therapy with a significant reduction of premature ovarian failure (POF) among premenopausal women with SLE. This association suggests that the addition of GnRH-a can be a strategy to prevent POF among premenopausal women with SLE after IVCY therapy.