Su G, Gao MX, Shi GL, et al. - In this study with 144 diabetic patients experiencing acute coronary syndrome (ACS), researchers assessed the predictive ability of 1,5-anhydroglucitol (1,5-AG) for the occurrence of coronary plaque rupture in this patient population. Experts found significantly lower serum 1,5-AG levels, longer duration of diabetes, higher hemoglobin A1c (HbA1c) and fasting blood glucose levels in patients with ruptured plaque vs those without ruptured plaque. Low 1,5-AG levels were identified as an independent predictor of plaque rupture in patients with diabetes and ACS, as shown in multivariate analysis. For the prediction of plaque rupture, 1,5-AG yielded an area under the receiver-operating characteristic curve of 0.658, which was superior to that for HbA1c (0.587). Overall, in this patient population, high risk for coronary plaque rupture may be detected with the help of serum 1,5-AG, this indicates a link of postprandial glucose excursions with the pathogenesis of plaque rupture in diabetes.