Ectopic expression of self-antigen drives regulatory T cell development and not deletion of autoimmune T cells
The Journal of Immunology Aug 29, 2017
Lee T, et al. – The goal of this study was to find out if ectopic expression of self–antigen driven regulatory T cell development and not deletion of autoimmune T cells. In this study, Ag dose and peptideÂMHC complex stability could lead to multiple fates of insulin–reactive CD4+ T cell development and autoimmune disease outcome.
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