O'Brien M, et al. - This study aimed to map the current market landscape of medical grade oxygen for use in cluster headache (CH) and to develop a cost simulator based on a patient's needs and geography, in the US states. The outcomes of this research revealed that in CH, the current costs for oxygen use as an acute therapy were not prohibitively expensive for patients and healthcare insurance providers. Many insurers reimbursed the cost of oxygen use for CH apart from Centers for Medicare and Medicaid Services (CMS). Additional study was required to ascertain if a lack of physician awareness about treatments and ways to prescribe were barriers for patients to access the high-flow oxygen treatment.