Law EF, et al. - Researchers investigated annual healthcare expenditures associated with childhood headache in the United States. In addition, they determined how psychiatric comorbidities influence the impact of headache on expenditures. Using a nationally representative sample of 34,633 children ages 2-17 from the 2012-2015 Medical Expenditure Panel Surveys, they identified 779 (weighted 2.6%) children who were having headache based on health service use associated with headache. The headache group was estimated to have 24.3% higher annual total healthcare expenditures ($3036 vs $2350). In the United States, the pediatric headache was estimated to be associated with total national expenditures of $1.1 billion annually. For the headache group, higher incremental expenditures were evident in correlation with depression and attention deficit/hyperactivity disorder (ADHD) (depression: $1815 vs $1409; ADHD: $4742 vs $2935); however, interactions between psychiatric comorbidities and headache did not reach statistical significance.