Lee OC, Cheng DC, Paul JL, et al. - This research sought to investigate the economic burden of self-reported penicillin allergies in total joint arthroplasty (TJA). Researchers collected data from studies reporting true incidence of IgE-mediated penicillin allergies, infection-free survivorship of TJA, and cost of prosthetic joint infection (PJI) attributed to the use of second-line antibiotics. They further computed the projected cost of preoperative penicillin allergy testing and potentially avoidable PJI correlated with second-line antibiotic usage. The results of this research demonstrate that preoperative penicillin allergy testing or risk stratification via thorough history should be implemented as a standard of care for patients with self-reported penicillin allergies before TJA and would result in a reduced cost of PJI.