Matsubara D, Kauffman HL, Wang Y, et al. - Researchers conducted this retrospective review to analyze echocardiographic manifestations in multisystem inflammatory syndrome in children (MIS-C). The sample consisted of 28 MIS-C, 20 healthy control subjects and 20 classic Kawasaki disease (KD) patients. Global longitudinal strain, global circumferential strain, peak left atrial strain, and peak longitudinal strain of right ventricular free wall were the strongest parameters to predict myocardial injury in MIS-C. In contrast to classic KD, coronary arteries may be spared in early MIS-C, however, myocardial injury is common. Even preserved EF patients displayed subtle changes in myocardial deformation, indicating subclinical myocardial injury. Strong improvement of systolic function but the persistence of diastolic dysfunction and no coronary aneurysms occurred during the abbreviated follow-up.