Kofoed KF, et al. - Researchers compared clinical outcomes between a strategy of very early invasive coronary angiography (ICA) and possible revascularization within 12 hours of diagnosis of non-ST-segment elevation acute coronary syndrome and an invasive strategy performed within 48 to 72 hours in the VERDICT trial (Very Early Versus Deferred Invasive Evaluation Using Computerized Tomography) participants (n=2,147) randomized 1:1 to ICA (1075 patients) at a median of 4.7 hours after randomization or standard invasive care (n=1072) with ICA performed 61.6 hours after randomization. The findings of a median follow-up time of 4.3 years revealed no improvement in overall long-term clinical outcome with a strategy of very early invasive coronary evaluation vs with an invasive strategy conducted within 2 to 3 days in patients with non-ST-segment elevation acute coronary syndrome. However, improved long-term outcomes were seen in patients with the highest risk.