Docherty AB, et al. – This study investigated the association of troponin I (TnI) with hospital mortality in critically ill patients and persistence of this link after adjusting for potential confounders. Furthermore, researchers assessed if addition of TnI to the Acute Physiological and Chronic Health Evaluation II (APACHE II) risk prediction model improves its performance in general intensive care unit (ICU) populations. TnI showed independent predictive ability for hospital mortality and correlated most highly with the acute physiology score (APS) component of APACHE II, however, failed to improve risk prediction. Researchers did not advocate the adoption of routine troponin analysis on admission to ICU, they recommended troponin assessment only in clinically indicated scenarios.