Achavanuntakul P, Manuskiatti W, Wanitphakdeedecha R, et al. - Currently, the first-line treatment for nevus of Ota is laser therapy. Researchers herein conducted a 10-year (2008–2018) retrospective cohort study of patients receiving laser therapy for nevus of Ota in order to determine the association between treatment efficacy and safety, risk of recurrence, and age of treatment initiation.

• Included were a total of 84 patients (aged 4 months–50 years) with nevus of Ota lesions.

• Treatment involved a 1,064-nm Q-switched Nd:YAG or a 755-nm or 1,064-nm picosecond-domain laser (or a combination thereof).

• In this patient cohort, significantly improved therapeutic outcomes and reduced risk of adverse events and recurrence were observed in correlation with initiation of laser treatment for nevus of Ota before the age of 5 years.