Chen YC, et al. - Using data from the Taiwan Children Health Study with longitudinal follow-ups of 2,991 children aged 11–17 years, researchers performed this longitudinal investigation to examine the causal link between pubertal maturation and asthma through Mendelian randomization (MR). They also determined how asthma is influenced by the coexistence of overweightness and early pubertal maturation. A link between early pubertal maturation and active asthma was shown by the findings of MR analysis; the significance of this effect was realized in male children. In both sexes, a significantly increased risk of incident asthma outcomes at 12 and 17 years of age was reported in relation to early pubertal maturation. In children of both sexes, a synergistic influence of overweightness and early pubertal maturation on asthma risk was evident, taking non-overweight and non–early puberty children as the reference group. For avoiding future early pubertal onset and asthma occurrence, experts recommended early screening and intervention for obesity.