Early pregnancy prediction of spontaneous preterm birth prior to 32 completed weeks of pregnancy using plasma RNA: Transcriptome discovery and initial validation of an RNA panel of markers
BJOG: An International Journal of Obstetrics and Gynaecology May 14, 2021
Weiner CP, Dong Y, Zhou H, et al. - Researchers conducted this prospective case‐control study to compare the second-trimester plasma cell‐free (PCF) transcriptome of women who delivered at term to women with spontaneous preterm birth (sPTB) ≦ 32weeks and identify/validate PCF ribonucleic acid (RNA) markers present by 16weeks. The sample consisted of 289 participants. In sPTB ≦ 32weeks, 297 PCR RNAs were differentially expressed. The PCF RNA markers are highly linked to sPTB ≦ 32weeks by 16 weeks.
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