Snyder BM, Baer RJ, Oltman SP, et al. - Researchers investigated the clinical utility of first and second trimester prenatal screening biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM) risk in nulliparous women via performing a population-based cohort study of 105,379 nulliparous women who participated in the California Prenatal Screening Program from 2009 to 2011. Observations revealed association of decreased levels of first trimester pregnancy-associated plasma protein A and increased levels of second trimester unconjugated estriol and dimeric inhibin A with GDM. However, their clinical utility for prediction of GDM risk is limited in nulliparous women.