Li K, Liu X, Yip R, et al. - The present study was performed to explore whether the extent of COVID-19 pneumonia on CT scans using quantitative CT imaging obtained early in the illness can predict its future severity. Between January 18, 2020, and March 5, 2020, researchers performed a retrospective single-center study on confirmed COVID-19 patients. Individuals were categorized as being in the severe or non-severe group based on their final symptoms. They applied penalized B-splines regression modeling to analyze the association between mean volume ratio and days from onset of symptoms in the two groups, with 95% and 99% confidence intervals. The results indicated that CT could predict the patients who later developed severe symptoms with 95% confidence, five days after the initial onset of symptoms.