Christensen MW, Kesmodel US, Christensen K, et al. - In view of the association of early and premature menopause with an raised risk of cardiovascular diseases (CVDs), osteoporosis and death, researchers here examined if young women with early ovarian ageing (EOA), defined as unexplained, and repeatedly few oocytes harvested in ART, are at an increased risk of age-related events. They performed a register-based national, historical cohort study including young women (≤ 37 years) having their first ART treatment in a public or private fertility clinic during the period 1995–2014; the women were divided into two groups based on their ovarian reserve status: EOA (n = 1,222) and NOA (n = 16,385). Morbidity and mortality were assessed using several national registers. Follow-up revealed an increased risk of age-related events among women with idiopathic EOA vs women with normal ovarian ageing (NOA). Stratifying on categories, the EOA group showed a significantly raised risk for CVD and osteoporosis.