Schlendorf K, et al. – In view of the shortage of suitable donor hearts, and the favorable drug profiles and efficacy of current agents used to treat Hepatitis C (HCV), authors performed transplantation of selected patients using HCV–positive donors. The use of HCV–positive donors seemed a potential approach to safely expand the donor pool in the presence of highly effective HCV pharmacotherapy. This report established that HCV treatment leads to rapid viral suppression early after transplant, despite immunosuppression. Authors recommend additional follow–up to determine long–term outcomes and assess for sustained virologic response.