Miles MR, Shetty PN, Bhayana K, et al. - In this study, the short-term outcomes of endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR), including patient-reported outcomes, pain and satisfaction scores, return to work, and postoperative prescription pain medication use was compared. Between January 2018 and December 2019, all patients over 18 years of age undergoing carpal tunnel release were included at a single-hand center. Researchers recruited a total of 678 (586 ECTR and 92 OCTR) patients (the median age was 58 years, and 75% of the patients were women). No evidence was observed implying the definitive superiority of 1 surgical technique with regard to clinical outcomes in the early postoperative period. Nevertheless, OCTR was correlated with lower postoperative patient-reported outcomes measurement information system upper-extremity scores of unclear clinical significance, higher odds of remaining on pain medication, and lower odds of returning to work by the first postoperative visit. The data illustrate that endoscopic carpal tunnel release may be preferred in patients who need to return to work within the first 2 weeks after the procedure.