Pennisi MA, et al. - In this single-center, randomized trial, authors examined 96 cases from September 2015 to April 2018 to estimate the comparative impact of preemptive high-flow nasal oxygen vs Venturi mask oxygen therapy on the incidence of postoperative hypoxemia after lung resection. About 81% in the high-flow group and 79% in the Venturi mask group developed postoperative hypoxemia. They recorded no inter-group differences with respect to the degree of dyspnea and the proportion of cases requiring oxygen therapy after treatment discontinuation, undergoing pulmonary complications or requiring ventilatory support. No variations were noticed in PaO₂/FiO₂ between the groups. They recorded that candidates receiving high-flow nasal oxygen had a reduced arterial pressure of carbon dioxide with a mean inter-group difference of 2 mmHg. Hence, they were noted burdened by a lower risk of postoperative hypercapnia.