Jepsen RK, et al. - Researchers performed global miRNA microarray using tissue samples from the invasive front of pT1 colorectal cancer (CRC) and examined relationships of the miR-17/92 cluster and presence of lymph node metastases (LNM). For this analysis, 56 matched pT1 CRCs were thoroughly clinico-pathologically characterized and miRNA microarrays were performed on invasive front tissue samples. In the invasive front of CRC, they found evidence for relationships between early regional LNM and high expression levels of the miR-17/92 cluster members: miR-17-3p and miR-92a. The outcomes supported a role for the miR-17/92 cluster in early metastatic progression of CRC.