Chang EH, et al. - Researchers sought to investigate early-life risk factors for adult sinusitis in a longitudinal cohort study (Tucson Children’s Respiratory Study). They successfully identified an early-onset chronic sinusitis phenotype, which was related to a predisposition to viral infections/colds in early life, allergies, and asthma. Association of early-onset chronic sinusitis with the following was reported: increased serum IgE levels as early as at 9 months of age, atopy (assessed by skin test reactivity), childhood eczema and allergic rhinitis, frequent childhood colds, maternal asthma, and with increased prevalence of concurrent asthma.