Oh H, Yaghjyan L, Austin-Datta RJ, et al. - Given that early-life and adult anthropometrics are related to breast density and breast cancer risk, researchers herein investigated if these factors also impact breast tissue composition beyond what is captured by breast density in females experiencing benign breast disease (BBD). A total of 788 controls from a nested case-control analysis of breast cancer within the Nurses' Health Study BBD subcohorts, were included. Higher proportions of adipose tissue and lower proportions of fibrous stromal tissue, during adulthood, were detected in relation to childhood body fatness (level ≥ 4.5 vs 1), BMI at age 18 (≥23 vs <19 kg/m²), and current adult BMI (≥30 vs <21 kg/m²). There was an inverse correlation of BMI at age 18 with epithelial tissue. Adult height was not related to any of the individual tissue types. Overall, findings are indicative of the long-term impacts of body fatness on breast tissue composition.