Pyne JH, et al. - Researchers investigated 1,296 cases of Invasive squamous cell carcinoma (SCC) assessing histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation, and anatomic site gathered over 9 years (from 2009 to 2017) to assess the recurrence rates of early invasive SCC. They observed the maximum average microscopic surface diameters ranged from 8.0 to 9.6 mm and maximum average depths from 1.3 to 2.5 mm. They noted 1.4, 1.1, and 1.3 mm of minimum average histopathologic margins for well, moderate, and poorly differentiated SCC, respectively. The rate of recurrence was observed as follows: 1.7% of well, 1.8% moderate and 6.4% in poorly differentiated SCC. Lip (7%) was recorded with the highest recurrence for well-differentiated SCC by anatomic site, followed by ear (4%).