Tukova J, et al. - In the present study, the researchers sought to analyze the impact of early inhaled corticosteroids on chronic respiratory morbidity. Fifty-nine survivors from the Prague cohort involved in Neonatal European Study of Inhaled Steroids underwent further follow-up covering of respiratory morbidity monitoring during the first 2 years of life followed by objective lung function testing performed at the age of 5.9 years (range 5-7 years). Fifty randomized (budesonide vs placebo group, 56% vs 44%) survivors have been involved in the study. The spirometry was performed successfully in 48 children. Children who were assigned to budesonide had a significantly lower rate of chronic lung disease symptoms than those assigned to placebo. The study suggests that early inhaled budesonide has been correlated with the trend towards improving functional lung parameters and a lower rate of chronic lung disease symptoms within the first 2 years of life.