Gillespie D, Knapper C, Hughes D, et al. - The present study was undertaken to present the early effect of COVID-19 and correlated control measures on the sexual behaviour of pre-exposure prophylaxis (PrEP) users in Wales. Researchers collected data from an ecological momentary assessment study of PrEP use and sexual behaviour. The results of this study indicate that introduction of social distancing measures and variations to PrEP services across Wales was correlated with a marked reduction in reported instances of condomless sexual intercourse among respondents, with a larger reduction in those who were single compared with those who were not. The long-term effect of COVID-19 and correlated control measures on this population’s physical and mental health and well-being needs close evaluation.