Shao J, Dai Z, Zhu R, et al. - Alterations in specific brain networks for depressed patients who transformed into bipolar disorder (BD) (tBD) from unipolar disorder (UD) were assessed via estimating the module allegiance from resting-fMRI by applying a multilayer modular method in 99 patients (33 tBD, 33 BD, 33 UD) and 33 healthy controls (HC). As per findings, the identification of BD from UD in the early stage could be done via estimating the functional declination of internal interaction in the default-mode network (DMN). Patients were identified to be at a higher predisposition to depressive states when higher recruitment of DMN was observed, while higher recruitment of SMN makes them more sensitive to external stimuli and prone to mania. Moreover, for identifying different stages of BD, cognitive control network (CCN) was suggested as a critical network. This indicates that CCN related cognitive impairments accompany the onset of mania in depressed patients.