Olsson KW, et al. - In extremely preterm infants, researchers evaluated whether early haemodynamically significant patent ductus arteriosus (hsPDA) predicted persistent PDA. This study was conducted at Uppsala University Children's Hospital from November 2012 to May 2015 on 60 infants born at 22-27 weeks of gestational age without any major congenital anomalies or heart defects. Investigators found that PDA was persistent in 30% and ultimately closed or insignificant in 70%. The results obtained from this prospective observational study indicate that early hsPDA did not predict persistent PDA, but in these extremely premature infants, the early need for assisted ventilation and low ductal Vmax (maximal ductal flow velocity) was linked to future persistent PDA.