Molitch ME, et al. - Given that glomerular hyperfiltration has been considered to be a contributing factor to the development of diabetic kidney disease (DKD), researchers examined participants from Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications study with type 1 diabetes and having undergone an ¹²⁵I-iothalamate clearance at DCCT baseline, to address this issue. They analyzed GFR follow-up data. Findings revealed no link between early hyperfiltration in patients with type 1 diabetes and a higher long-term risk of reduced GFR. In DKD, although glomerular hypertension could be a mechanism of kidney injury, higher total GFR was not recognized as a risk factor for advanced DKD.