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Early gestational diabetes (GDM) is associated with worse pregnancy outcomes compared with GDM diagnosed at 24-28 weeks gestation despite early treatment

QJM: An International Journal of Medicine May 20, 2020

Mustafa M, Bogdanet D, Khattak A, et al. - Women with GDM diagnosed < 24weeks gestation were compared with those diagnosed at 24-28 weeks in a large Irish cohort regarding pregnancy outcomes. Researchers conducted a retrospective cohort study of 1,471 pregnancies in women with GDM diagnosed using IADPSG criteria between September 2012- April 2016. They observed significantly greater risk of pregnancy induced hypertension (12.4% vs 5.3%), postpartum haemorrhage (8.7% vs 2.4%) and postpartum glucose abnormalities (32% vs 15.6%) among women with early GDM. Further, offspring of these women had a greater risk of prematurity (10.9% vs 6.6%), stillbirth (1.4% vs 0.5%), large for gestational age 19.1% v 13.4% and need neonatal intensive care 30.7% vs 22.1% compared with offspring of women with standard GDM. The early GDM group still showed higher rates of C-section and prematurity when the two groups were compared based on their postnatal OGTT. Early GDM may suggest a more advanced state in diabetes pathogenesis given the abnormal post-natal glucose findings.

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