Lopes CLS, et al. - Researchers conducted this retrospective cohort study to assess the impact of early fluid overload on critically ill children admitted to a paediatric intensive care unit by evaluating mechanical ventilation (MV), mortality, length of stay and renal replacement therapy. This research focused on all MV support episodes that exceeded 24 hours. One hundred eighty-six MV episodes in 154 individuals were included. In the first 72 hours, the median fluid overload percentage (FO%) was 8.0% (IQR 3.6%-11.2%). An early cumulative FO of ≥ 10% was linked to more aggressive ventilatory parameters and prolonged length of MV in a heterogeneous paediatric population given MV, but not mortality.