Curry N, et al. - In this pragmatic study involving adult trauma patients with active bleeding who required activation of the major haemorrhage protocol, researchers evaluated the feasibility of fibrinogen concentrate administration within 45 minutes of hospital admission and assessed efficacy in maintaining fibrinogen levels ≥ 2 g/L during active haemorrhage. This study was conducted at five UK major trauma centres. Standard major haemorrhage therapy plus 6 g of fibrinogen concentrate or placebo were administered to patients. Findings showed the non-feasibility of early delivery of fibrinogen concentrate within 45 minutes of admission. Fibrinogen was indicated to have a key role in the treatment of major bleeding.