Yu J, Zhong N, Luo Q, et al. - Researchers conducted this randomized, open-label study to compare the early effectiveness and safety of cluster and conventional immunotherapies for patients with allergic rhinitis (AR). Participants in the study were 149 patients with persistent AR. Study participants were divided into the following four groups: 60 children treated conventionally, 33 children treated using the cluster schedule, 23 adults treated conventionally, and 33 adults treated using the cluster schedule. To assess clinical effectiveness and adverse reactions, symptom scores and skin prick test scores (SPTs) were used. There were no significant differences in the efficacy of nasal symptoms scores among four groups, but the effectiveness of SPTs using conventional schedule was higher than cluster schedule in children groups. The findings indicate that both for children and adults conventional immunotherapy and cluster immunotherapy are effective and safe. The authors also discovered that SPT can provide substantial guidance for clinical outcome assessment.