Zhong Y, et al. - Considering the significance of early diagnosis of acute fatty liver of pregnancy (AFLP) for lowering the related mortality rate and that some terms of the Swansea criteria , the commonly used method to diagnose AFLP, could only be reached when symptoms and signs have progressed, which make it inefficient in clinical practice, researchers sought for cost effective tests to simplify and facilitate early suspicion of acute fatty liver of pregnancy. In this retrospective study, they reviewed 28,800 medical records at the Second Xiangya Hospital from 2009 to 2015, and included 41 patients with AFLP and 172 other diseases that could show similar symptoms to AFLP. AFLP was observed to be significantly associated with following variables: gastrointestinal symptoms, blood pressure > 140/90 mmHg, aminotransferase > 42 IU/l, total bilirubin > 0.8 mg/dl, total bilirubin acid > 10.0 μmol/L, activated partial prothrombin time(APTT) > 34 s, prothrombin time(PT) > 14 s, white blood cells > 11 *106/l and blood sugar < 72 mg/dl. They achieved 97.6% sensitivity and 97.1% specificity to diagnose AFLP with gastrointestinal symptoms +aminotransferase +bilirubin +bile acid +APTT/PT. Hence for earlier identification of AFLP, high diagnostic accuracy was attained with a statistical model that included maternal symptoms, biochemical and haematological parameters.