Ambalavanan N, Shankaran S, Laptook AR, et al. - Since the early determination of prognosis is important in neonates with hypoxic-ischemic encephalopathy (HIE), researchers sought to test scoring systems developed earlier (original scoring system) and develop new prognostic models. Secondary analysis of data from 364 neonates with moderate or severe HIE who were enrolled in a multicenter randomized controlled trial of longer, deeper, or usual care cooling in neonatal HIE. For death or disability, the original scoring system correctly classified 75%, while the new scoring system correctly classified 78%, and the CART model accurately classified 76%. In terms of predicting mortality or disability, the 3 models (scoring system, CART, and early neurologic evaluation) were equal. CART models outperformed scoring systems and early neurologic assessment for in-hospital death.