Patil SU, Steinbrecher J, Calatroni A, et al. - In a single-center, open-label peanut OIT (oral immunotherapy) trial, researchers investigated whether alterations in basophil sensitivity and AUC (Area under the curve) to the immunodominant allergen Ara h 2 correlated with clinical responses to OIT. Participants were peanut-allergic children, aged 7-13. Successful treatment with OIT was achieved in 22 of 30 participants; post-avoidance, sustained unresponsiveness (SU) and transient desensitization (TD) were reported in 9 and 13 children, respectively. Findings revealed a correlation between early decreases in basophil sensitivity to Ara h 2 and SU. After avoidance, basophil AUC rebounded in TD. Thus, the possible utility of different aspects of basophil activation for monitoring of OIT efficacy was suggested.