Fortuni F, Crimi G, Angelini F, et al. - Via a systematic review and meta-analysis, researchers compared early complete revascularization (defined as complete revascularization achieved during the index procedure or within 72 hours) with culprit-only or staged revascularization, in terms of efficacy and safety, in hemodynamically stable patients with ST-segment elevation myocardial infarction and multivessel disease. They analyzed evidence from 9 randomized clinical trials including 2,837 patients, identified from the literature. They found that a lower risk of major adverse cardiovascular events, myocardial infarction, and repeat revascularization was reported in relation to early complete revascularization vs culprit-only or staged revascularization. However, these strategies did not differ in terms of all-cause mortality and safety outcomes. Therefore, considering early complete revascularization was recommended in this patient population deemed suitable for percutaneous interventions. In attenuating the requirement for further interventions, a possible superiority of fractional flow reserve-guided complete revascularization over angiography-guided procedures was suggested.